Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats.
Yoshio OguraMunehiro KitadaItaru MonnoKeizo KanasakiAi WatanabeDaisuke KoyaPublished in: Redox report : communications in free radical research (2018)
Enhancement of mitochondrial oxidative stress in the diabetic kidney was mediated by the reduction of Sirt3 activity. CD38 overexpression may be related to a reduction in the NAD+/NADH ratio in the diabetic kidney.