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Halting the Canadian STRIDER randomised controlled trial of sildenafil for severe, early-onset fetal growth restriction: ethical, methodological, and pragmatic considerations.

Peter Von DadelszenFrançois AudibertEmmanuel BujoldJeffrey N BoneAsh SandhuJing LiChirag KariyaYoukee ChungTang LeeKelvin AuM Amanda SkollMarianne VidlerLaura A MageeBruno PiedboeufPhilip N BakerSayrin LaljiKenneth I Lim
Published in: BMC research notes (2022)
Between May 2017 and June 2018, 21 (90 planned) women were randomised [10 sildenafil; 11 placebo (1 withdrawal)]. Baseline characteristics, PLGF levels, maternal and perinatal outcomes, and adverse events did not differ. Delivery GA: 26 + 6 weeks (sildenafil) vs 29 + 2 weeks (placebo); p = 0.200. Data will contribute to an individual participant data meta-analysis.
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