Alterations of oncogenes expression in NK cells in patients with cancer.
Gulnur K ZakiryanovaElena KustovaNataliya T UrazalievaAday AmirbekovEmile T BaimuchametovNarymzhan N NakisbekovMichael R ShurinPublished in: Immunity, inflammation and disease (2017)
We suggest that the abnormal signaling and expression of c-kit/SCF, c-myc, and STAT3 in NK cells is responsible for the defect in their cytolytic activity in cancer and these defects at the gene expression level may be the cause rather than the result of tumor progression.