Effect of Fatty Acid Composition in Polysorbate 80 on the Stability of Therapeutic Protein Formulations.

Melissa A PeguesKarol SzczepanekFaruk SheikhSeth G ThackerBaikuntha AryalMohamed K GhorabSteven WolfgangRaymond P DonnellyDaniela VerthelyiV Ashutosh Rao

Published in: Pharmaceutical research (2021)

These results suggest that composition of fatty acids in polysorbate 80 may be a promoter for sub-visible particulate formation under the stress conditions tested but may not impact protein aggregation or biological activity.

Keyphrases

fatty acid
protein protein
dna methylation
amino acid
gene expression
binding protein
transcription factor
small molecule