Tocilizumab has no direct effect on cell lines infected with human T-cell leukemia virus type 1.

Yushiro EndoShoichi FukuiTomohiro KogaDaisuke SasakiHiroo HasegawaKatsunori YanagiharaAkihiko OkayamaTatsufumi NakamuraAtsushi KawakamiHideki Nakamura

Published in: The Journal of international medical research (2021)

TCZ had no effect the cytokine profiles, HTLV-1 gene and protein expression, PVL, or apoptosis in HTLV-1-infected T-cell lines. Thus, TCZ treatment has no effect on HTLV-1 infection in vitro.

Keyphrases

endothelial cells
oxidative stress
rheumatoid arthritis
bone marrow
acute myeloid leukemia
cell death
cell proliferation
copy number
combination therapy
rheumatoid arthritis patients
replacement therapy
disease activity