Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells.

Julian PulecioZakieh TayyebiDingyu LiuWilfred WongRenhe LuoJeyaram R DamodaranSamuel KaplanHyunwoo ChoJielin YanDylan MurphyRobert W RickertAbhijit ShuklaAaron ZhongFederico GonzálezDexin YangWenbo LiTing ZhouEffie ApostolouChristina S LeslieDanwei Huangfu

Published in: bioRxiv : the preprint server for biology (2023)

We report a class of distal regulatory regions distinct from enhancers that confer human embryonic stem cells with the competence to rapidly activate the expression of lineage-specific genes.

Keyphrases

embryonic stem cells
endothelial cells
induced pluripotent stem cells
genome wide
gene expression
poor prognosis
small molecule
dna damage
single cell
long non coding rna
bioinformatics analysis