The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) Index: A Prognostic Tool for Children.
Mark R DeneauCara MackEmily R PeritoAmanda RicciutoPamela L ValentinoMansi AminAchiya Z AmirMadeleine AumarMarcus AuthAnnemarie BroderickMatthew DiGuglielmoLaura G DraijerEleonora Druve Tavares FagundesWael El-MataryFederica FerrariKatryn N FuruyaNitika Arora GuptaJessica T HochbergMatjaz HomanSimon HorslenRaffaele IorioM Kyle JensenMaureen M JonasBinita M KamathNanda KerkarKyung Mo KimKaija-Leena KolhoBart G P KootTrevor J LabordaChristine K LeeKathleen M LoomesMercedes MartinezAlexander MiethkeTamir MilohDouglas MogulSaeed MohammadParvathi MohanStacy MorozNadia OvchinskySirish PalleAlexandra PapadopoulouGirish RaoAlexandre Rodrigues FerreiraPushpa SathyaKathleen B SchwarzUzma ShahEyal ShteyerRuchi SinghVratislav SmolkaNisreen SoufiAtsushi TanakaRaghu VarierBernadette VitolaMarek WoynarowskiMelissa ZerofskyAndréanne N ZizzoStephen L GutheryPublished in: Hepatology (Baltimore, Md.) (2020)
The SCOPE index is a pediatric-specific prognostic tool for PSC. It uses routinely obtained, objective data to predict a complicated clinical course. It correlates strongly with biopsy-proven liver fibrosis. SCOPE can be used with families for shared decision making on clinical care based on a patient's individual risk, and to account for variable disease progression when designing future clinical trials.
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