Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer.
Rayna RosatiLisa PolinCharles DuckerJing LiXun BaoDakshnamurthy SelvakumarSeongho KimBesa XhabijaMartha LarsenThomas McFallYanfang HuangBenjamin L KidderAndrew FribleyJanice SaxtonHiroki KakutaPeter E ShawManohar RatnamPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
The results offer a mechanism-based therapeutic paradigm for disrupting the AR growth-promoting axis in the spectrum of prostate tumors while reducing global suppression of testosterone actions. KCI807 offers a good lead molecule for drug development.