Hiroki Kakuta

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 19

Top Venues

Journal of medicinal chemistry

ACS medicinal chemistry letters

FEBS letters

ACS pharmacology & translational science

Okayama University

University of Tokyo (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Okayama University Oct 01 2008

Japan

Associate Professor :: Graduate School of Medicine, Dentistyry, adn Pharmaceutical Sciences

Education History

University of Tokyo Apr 01 1998 - Mar 27 2003

Japan

PHD :: Graduate School of Pharmaceutical Sciences

Publications

Yukina Tanaka, Michiko Fujihara, Yuta Takamura, Mayu Kawasaki, Shogo Nakano, Makoto Makishima, Hiroki Kakuta
Simple Fluorescence Labeling Method Enables Detection of Intracellular Distribution and Expression Level of Retinoid X Receptors. ACS medicinal chemistry letters 15 (5) (2024)
Yukina Tanaka, Michiko Fujihara, Yuta Takamura, Mayu Kawasaki, Shogo Nakano, Makoto Makishima, Hiroki Kakuta
Simple Fluorescence Labeling Method Enables Detection of Intracellular Distribution and Expression Level of Retinoid X Receptors. ACS medicinal chemistry letters 15 (5) (2024)
Mayu Kawasaki, Tomoharu Motoyama, Shoya Yamada, Masaki Watanabe, Michiko Fujihara, Akira Kambe, Shogo Nakano, Hiroki Kakuta, Sohei Ito
Ligand Screening System for the RXRα Heterodimer Using the Fluorescence RXR Agonist CU-6PMN. ACS medicinal chemistry letters 14 (3) (2023)
Negar Khazan, Kyu Kwang Kim, Jeanne N Hansen, Niloy A Singh, Taylor Moore, Cameron W A Snyder, Ravina Pandita, Myla Strawderman, Michiko Fujihara, Yuta Takamura, Ye Jian, Nicholas Battaglia, Naohiro Yano, Yuki Teramoto, Leggy A Arnold, Russell Hopson, Keshav Kishor, Sneha Nayak, Debasmita Ojha, Ashoke Sharon, John M Ashton, Jian Wang, Michael T Milano, Hiroshi Miyamoto, David C Linehan, Scott A Gerber, Nada Kawar, Ajay P Singh, Erdem D Tabdanov, Nikolay V Dokholyan, Hiroki Kakuta, Peter W Jurutka, Nina F Schor, Rachael B Rowswell-Turner, Rakesh K Singh, Richard G Moore
Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo . Journal of medicinal chemistry 65 (8) (2022)
Masaki Watanabe, Mariko Nakamura-Nakayama, Michiko Fujihara, Mayu Kawasaki, Shogo Nakano, Hiroki Kakuta
Increased Molecular Flexibility Widens the Gap between K i and K d values in Screening for Retinoid X Receptor Modulators. ACS medicinal chemistry letters 13 (2) (2022)
Yuta Takamura, Izumi Kato, Manami Fujita-Takahashi, Midori Azuma-Nishii, Masaki Watanabe, Rui Nozaki, Masaru Akehi, Takanori Sasaki, Hiroyuki Hirano, Hiroki Kakuta
Teratogenicity and Fetal-Transfer Assessment of the Retinoid X Receptor Agonist Bexarotene. ACS pharmacology & translational science 5 (9) (2022)
Yuta Takamura, Hiroki Kakuta
In Vivo Receptor Visualization and Evaluation of Receptor Occupancy with Positron Emission Tomography. Journal of medicinal chemistry 64 (9) (2021)
Maho Takioku, Yuta Takamura, Michiko Fujihara, Masaki Watanabe, Shoya Yamada, Mayu Kawasaki, Sohei Ito, Shogo Nakano, Hiroki Kakuta
Creation of Fluorescent RXR Antagonists Based on CBTF-EE and Application to a Fluorescence Polarization Binding Assay. ACS medicinal chemistry letters 12 (6) (2021)
Masaki Watanabe, Michiko Fujihara, Tomoharu Motoyama, Mayu Kawasaki, Shoya Yamada, Yuta Takamura, Sohei Ito, Makoto Makishima, Shogo Nakano, Hiroki Kakuta
Discovery of a "Gatekeeper" Antagonist that Blocks Entry Pathway to Retinoid X Receptors (RXRs) without Allosteric Ligand Inhibition in Permissive RXR Heterodimers. Journal of medicinal chemistry 64 (1) (2020)
Ikuo Kimura, Junki Miyamoto, Ryuji Ohue-Kitano, Keita Watanabe, Takahiro Yamada, Masayoshi Onuki, Ryo Aoki, Yosuke Isobe, Daiji Kashihara, Daisuke Inoue, Akihiko Inaba, Yuta Takamura, Satsuki Taira, Shunsuke Kumaki, Masaki Watanabe, Masato Ito, Fumiyuki Nakagawa, Junichiro Irie, Hiroki Kakuta, Masakazu Shinohara, Ken Iwatsuki, Gozoh Tsujimoto, Hiroaki Ohno, Makoto Arita, Hiroshi Itoh, Koji Hase
Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice. Science (New York, N.Y.) 367 (6481) (2020)
Hend M Nawara, Said M Afify, Ghmkin Hassan, Maram H Zahra, Marwa N Atallah, Hager Mansour, Hagar A Abu Quora, Md Jahangir Alam, Michael P Lisanti, Hiroki Kakuta, Hiroki Hamada, Akimasa Seno, Masaharu Seno
Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells. Cancers 12 (6) (2020)
Kayo Yukawa-Takamatsu, Yifei Wang, Masaki Watanabe, Yuta Takamura, Michiko Fujihara, Mariko Nakamura-Nakayama, Shoya Yamada, Shota Kikuzawa, Makoto Makishima, Mayu Kawasaki, Sohei Ito, Shogo Nakano, Hiroki Kakuta
Convenient Retinoid X Receptor Binding Assay Based on Fluorescence Change of the Antagonist NEt-C343. Journal of medicinal chemistry 64 (1) (2020)
Shoya Yamada, Mayu Kawasaki, Michiko Fujihara, Masaki Watanabe, Yuta Takamura, Maho Takioku, Hiromi Nishioka, Yasuo Takeuchi, Makoto Makishima, Tomoharu Motoyama, Sohei Ito, Hiroaki Tokiwa, Shogo Nakano, Hiroki Kakuta
Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening. Journal of medicinal chemistry 62 (19) (2019)
Noriko Itaba, Yohei Kono, Kaori Watanabe, Tsuyoshi Yokobata, Hiroyuki Oka, Mitsuhiko Osaki, Hiroki Kakuta, Minoru Morimoto, Goshi Shiota
Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets. Scientific reports 9 (1) (2019)
Osamu Shibahara, Masaki Watanabe, Yuta Takamura, Shoya Yamada, Masaru Akehi, Takanori Sasaki, Akiya Akahoshi, Takahisa Hanada, Hiroyuki Hirano, Shunsuke Nakatani, Hiromi Nishioka, Yasuo Takeuchi, Hiroki Kakuta
Correction to Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Imaging Thereof. Journal of medicinal chemistry 62 (9) (2019)
Rayna Rosati, Lisa Polin, Charles Ducker, Jing Li, Xun Bao, Dakshnamurthy Selvakumar, Seongho Kim, Besa Xhabija, Martha Larsen, Thomas McFall, Yanfang Huang, Benjamin L Kidder, Andrew Fribley, Janice Saxton, Hiroki Kakuta, Peter E Shaw, Manohar Ratnam
Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 24 (24) (2018)
Yurina Miyashita, Nobutaka Numoto, Sundaram Arulmozhiraja, Shogo Nakano, Naoya Matsuo, Kanade Shimizu, Osamu Shibahara, Michiko Fujihara, Hiroki Kakuta, Sohei Ito, Teikichi Ikura, Nobutoshi Ito, Hiroaki Tokiwa
Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα). FEBS letters 593 (2) (2018)
Masaki Watanabe, Hiroki Kakuta
Retinoid X Receptor Antagonists. International journal of molecular sciences 19 (8) (2018)
Osamu Shibahara, Masaki Watanabe, Shoya Yamada, Masaru Akehi, Takanori Sasaki, Akiya Akahoshi, Takahisa Hanada, Hiroyuki Hirano, Shunsuke Nakatani, Hiromi Nishioka, Yasuo Takeuchi, Hiroki Kakuta
Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Imaging Thereof. Journal of medicinal chemistry 60 (16) (2017)

Hiroki Kakuta

Publication Activity (10 Years)

Top Topics

Top Venues