CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome.

Ludovica CelliPatrizia GaspariniGinevra BiinoLaura ZanniniMiriana Cardano

Published in: Cell & bioscience (2024)

This study, besides proposing a novel approach to investigate sex-biased physiological and pathological conditions, highlights new roles for the Y chromosome in the sexual dimorphism characterizing human health and diseases. Moreover, this analysis paves the way for the research of new therapeutic approaches for sex dimorphic and LOY-related diseases.

Keyphrases

human health
crispr cas
risk assessment
genome editing
copy number
climate change
genome wide
rna seq