Identifying Genetic Loci and Phenomic Associations of Substance Use Traits: A Multi-trait Analysis of GWAS (MTAG) study.

Heng XuSylvanus ToikumoRichard C CristKlaudia GlogowskaZeal JinwalaJoseph D DeakAmy C JusticeJoel GelernterEmma C Johnson Henry R Kranzler Rachel L Kember

Published in: Addiction (Abingdon, England) (2023)

Multi-trait analysis of genome-wide association studies (MTAG) boosted the number of loci found for substance use traits, identifying genes not previously linked to any substance, and increased the power of polygenic risk scores. MTAG can be used to identify novel associations for substance use, especially those for which the samples are smaller than those for historically legal substances.

Keyphrases

genome wide
genome wide association
dna methylation
copy number
gene expression
drinking water
case control