Fatty acid oxidation is critical for the tumorigenic potential and chemoresistance of pancreatic cancer stem cells.

Marta MascaraqueSarah CourtoisAlba Royo-GarcíaDavid BarnedaAndrei M StoianIsabel VillaosladaPilar Espiau-RomeraAnsooya BokilAndrés Cano-GalianoPetra JagustChristopher HeeschenPatricia Sancho

Published in: Journal of translational medicine (2024)

Targeting FAO inhibition represents a promising therapeutic strategy against this highly tumorigenic population.

Keyphrases

cancer stem cells
fatty acid
cancer therapy
hydrogen peroxide
drug delivery
nitric oxide
electron transfer