Improving Traditional Registrational Trial Endpoints: Development and Application of a Desirability of Outcome Ranking (DOOR) Endpoint for Complicated Urinary Tract Infection Clinical Trials.
Jessica R Howard-AndersonToshimitsu HamasakiWeixiao DaiDeborah CollyarDaniel RubinSumathi NambiarTori KinamonCarol HillSteven P GeloneDavid MarianoTakamichi BabaThomas L HollandSarah B DoernbergHenry F ChambersVance G FowlerScott R EvansHelen W BoucherPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
DOOR can effectively be utilized in registrational cUTI trials. The DOOR endpoint presented here can be adapted for other infectious diseases syndromes and prospectively incorporated into future clinical trials.