Investigating association of perineural invasion on prostate biopsy with Gleason score upgrading at prostatectomy: A multi-institutional analysis.
Andrew R BarskyRyan D KrausRuben CarmonaPatricia M G SantosCarrie LiLauren E SchwartzLeslie K BallasNeha VapiwalaPublished in: Cancer medicine (2020)
In post-prostatectomy patients with favorable-risk PC, PNI on prostate biopsy was not associated with surgical Gleason score upgrading. This may be due to the association of PNI with more diffuse disease, leading to increased biopsy tumor yield and grading accuracy. These findings suggest that in this setting, biopsy PNI alone should not be a concern for more aggressive disease requiring pathologic confirmation or intervention. This may help guide treatment decision-making for men debating active surveillance, radiation, and surgery.
Keyphrases
- prostate cancer
- ultrasound guided
- fine needle aspiration
- benign prostatic hyperplasia
- decision making
- radical prostatectomy
- minimally invasive
- robot assisted
- randomized controlled trial
- squamous cell carcinoma
- coronary artery bypass
- atrial fibrillation
- acute coronary syndrome
- percutaneous coronary intervention
- surgical site infection