Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study.
Xingqi CaoXueqin LiJingyun ZhangXiaoyi SunGan YangYining ZhaoShu-Juan LiEmiel O HoogendijkXiao-Feng WangYimin ZhuHeather G AlloreThomas M GillZuyun LiuPublished in: JMIR public health and surveillance (2023)
In UK Biobank participants with prediabetes, both prefrailty and frailty are significantly associated with higher risks of multiple adverse outcomes, including T2DM, diabetes-related diseases, and all-cause mortality. Our findings suggest that frailty assessment should be incorporated into routine care for middle-aged adults with prediabetes, to improve the allocation of health care resources and reduce diabetes-related burden.