Upregulation of pAKT(Ser473) expression in progression of HPV-positive oropharyngeal squamous cell carcinoma.

Dominik HornChristian FreudlspergerDana HolzingerKevin KunzmannPeter PlinkertGerhard DyckhoffJürgen HoffmannKolja FreierJochen Hess

Published in: Head & neck (2017)

Activation of phosphoinositide 3-kinase (PI3K)/pAKT(Ser473) frequently occurs in advanced HPV-positive oropharyngeal SCC and elevated pAKT(Ser473) levels represent a feature during progression of oropharyngeal SCC, indicating a critical role of the mammalian target of rapamycin (mTOR) complex. Further studies are required to evaluate specific drugs targeting PI3K/AKT/mTOR in consideration of PIK3CA alterations.

Keyphrases

squamous cell carcinoma
poor prognosis
high grade
cell proliferation
protein kinase
machine learning
deep learning
signaling pathway
long non coding rna
cervical cancer screening
cancer therapy
binding protein
tyrosine kinase
locally advanced
radiation therapy
rectal cancer