A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension.
Xincheng LiShuangshuang MaQi WangYishan LiXiaofan JiJixiang LiuJing MaYongbing WangZhu ZhangHong ZhangHong ChenLinfeng XiYunxia ZhangWanmu XieLu SunZhihui FuPeiran YangChen WangZhen-Guo ZhaiPublished in: Journal of translational medicine (2024)
Our study identified a new inflammatory pathway in IPAH, where T and NK cells drove heightened inflammation predominantly via the upregulation of CCL5, providing groundwork for the development of targeted therapeutics.
Keyphrases
- nk cells
- rna seq
- single cell
- pulmonary arterial hypertension
- oxidative stress
- induced apoptosis
- pulmonary artery
- pulmonary hypertension
- high throughput
- liver injury
- liver fibrosis
- cell cycle arrest
- small molecule
- poor prognosis
- signaling pathway
- cancer therapy
- drug induced
- endoplasmic reticulum stress
- african american