Heterozygous rare genetic variants in non-syndromic early-onset obesity.

Clara Serra-JuhéGabriel Á Martos-MorenoFrancesc Bou de PieriRaquel FloresJulia A Chowen Luis Alberto Pérez-Jurado Jesús Argente

Published in: International journal of obesity (2005) (2019)

Heterozygous RSVs in several candidate genes of the melanocortin pathway are found in ~5.0% patients with EOO. These results support the clinical utility of genetic testing to identify patients who might benefit from targeted therapeutic intervention.

Keyphrases

early onset
late onset
randomized controlled trial
insulin resistance
metabolic syndrome
weight loss
intellectual disability
type diabetes
cancer therapy
weight gain
high fat diet induced
drug delivery
body mass index