Comparison of Effectiveness Among Different Sodium-Glucose Cotransoporter-2 Inhibitors According to Underlying Conditions: A Network Meta-Analysis of Randomized Controlled Trials.
Ryoma KaniAtsuyuki WatanabeYoshihisa MiyamotoKentaro EjiriMasao IwagamiHisato TakagiLeandro SlipczukYusuke TsugawaTadao AikawaToshiki KunoPublished in: Journal of the American Heart Association (2024)
The differences in reducing cardiovascular and kidney outcomes as well as safety profiles across SGLT2 inhibitors were not consistently significant, although empagliflozin might be preferred in patients without chronic kidney disease. Further investigations are needed to better understand the mechanism and clinical effectiveness of each SGLT2 inhibitor in certain populations.