N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1.

Jing LiXiaohong XuKaihao XuXueliang ZhouKunpeng WuYuan YaoZaoqu LiuChen ChenLing WangZhenqiang SunDechao JiaoXin-Wei Han

Published in: Journal of experimental & clinical cancer research : CR (2024)

Taken together, m6A-modified circSLCO1B3 was correlated with poor prognosis in ICC and promoted ICC progression not only by enhancing proliferation and metastasis via potentiating HOXC8 expression, but also by inducing immune evasion via antagonizing PD-L1 degradation. These results suggest that circSLCO1B3 is a potential prognostic marker and therapeutic target for ICC.

Keyphrases

poor prognosis
long non coding rna
signaling pathway
risk assessment
human health
climate change