Hypoxia-inhibited DUSP2 expression promotes IL-6/STAT3 signaling in endometriosis.

Kuei-Yang Hsiao Ning ChangJia-Ling TsaiShih-Chieh LinShaw-Jenq TsaiMeng-Hsing Wu

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2017)

Hypoxia-induced IL-6 production in endometriotic lesions is mediated via downregulation of DUSP2, which causes aberrant activation of STAT3 signaling pathway and helps the endometriotic cells survive under the ectopic environment.

Keyphrases

signaling pathway
induced apoptosis
cell proliferation
pi k akt
cell cycle arrest
poor prognosis
endoplasmic reticulum stress
endothelial cells
epithelial mesenchymal transition
binding protein
cell death
long non coding rna