Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration.
Marta RoccioAlbert S B EdgePublished in: Development (Cambridge, England) (2019)
The development of therapeutic interventions for hearing loss requires fundamental knowledge about the signaling pathways controlling tissue development as well as the establishment of human cell-based assays to validate therapeutic strategies ex vivo Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how they offer for the first time the opportunity to validate drug-based therapies, gene-targeting approaches and cell replacement strategies.
Keyphrases
- stem cells
- single cell
- pluripotent stem cells
- cell therapy
- healthcare
- induced apoptosis
- endothelial cells
- hearing loss
- signaling pathway
- physical activity
- spinal cord
- induced pluripotent stem cells
- gene expression
- high throughput
- oxidative stress
- bone marrow
- cell proliferation
- genome wide
- cancer therapy
- mesenchymal stem cells
- cell death
- electronic health record