Exon skipping of TGFβRI affects signalling and ECM expression in hypertrophic scar-derived fibroblasts.

Rajiv S RaktoeMarion H RietveldJacoba J Out-LuitingMarianna Kruithof-de JulioPaul Pm van ZuijlenRemco van DoornAbdoelwaheb El Ghalbzouri

Published in: Scars, burns & healing (2020)

Exon skipping is a promising tool to modulate the TGF-β signalling pathway in HS. This would open a therapeutic window for the treatment of patients suffering from HSs.

Keyphrases

transforming growth factor
extracellular matrix
poor prognosis
minimally invasive
epithelial mesenchymal transition
binding protein
wound healing
signaling pathway