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Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival.

Praveen K BommareddyHiroaki WakimotoRobert L MartuzaHoward L KaufmanSamuel D RabkinDipongkor Saha
Published in: Journal for immunotherapy of cancer (2024)
Our findings illustrate that G47Δ-mIL2 is efficacious, stimulates antitumor immunity against orthotopic GBM, and may also target GSC. OHSV expressing IL-2 may represent an agent that merits further exploration in patients with GBM.
Keyphrases
  • herpes simplex virus
  • solid phase extraction
  • wild type