Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function.
Xixi ZhaoYongkun WeiYu-Yi ChuYintao LiJung-Mao HsuZhou JiangChunxiao LiuJennifer L HsuWei-Chao ChangRi-Yao YangLi-Chuan ChanJingkun QuShuqun ZhangHaoqiang YingDihua YuMien-Chie HungPublished in: Cancer research (2022)
This work identifies a role for CK2 in immunosuppression by phosphorylation and stabilization of PD-L1, identifying CK2 inhibition as an immunotherapeutic approach for treating cancer.