Mien-Chie Hung (Mie-Chie Hung)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 72

Top Venues

Nature communications

eLife

Cancer discovery

Science advances

China Medical University

Brandeis University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

China Medical University Feb 18 2019

Taiwan

President

The University of Texas MD Anderson Cancer Center - Feb 17 2019

United States

Professor and Chair :: Molecular and Cellular Oncology

Education History

Brandeis University

United States

PHD

Publications

Arseniy E Yuzhalin, Frank J Lowery, Yohei Saito, Xiangliang Yuan, Jun Yao, Yimin Duan, Jingzhen Ding, Sunil Acharya, Chenyu Zhang, Abigail Fajardo, Hao-Nien Chen, Yongkun Wei, Yutong Sun, Lin Zhang, Yi Xiao, Ping Li, Philip L Lorenzi, Jason T Huse, Huihui Fan, Zhong-Ming Zhao, Mien-Chie Hung, Dihua Yu
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition. Nature cell biology (2024)
Chunxiao Liu, Chenhao Zhou, Weiya Xia, Yifan Zhou, Yufan Qiu, Jialei Weng, Qiang Zhou, Wanyong Chen, Ying-Nai Wang, Heng-Huan Lee, Shao-Chun Wang, Ming Kuang, Dihua Yu, Ning Ren, Mien-Chie Hung
Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma. Nature communications 15 (1) (2024)
Guang Lei, Chao Mao, Amber D Horbath, Yuelong Yan, Shirong Cai, Yao Jun, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy Anthony Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer discovery 14 (8) (2024)
Chunxiao Liu, Chenhao Zhou, Weiya Xia, Yifan Zhou, Yufan Qiu, Jialei Weng, Qiang Zhou, Wanyong Chen, Ying-Nai Wang, Heng-Huan Lee, Shao-Chun Wang, Ming Kuang, Dihua Yu, Ning Ren, Mien-Chie Hung
Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma. Nature communications 15 (1) (2024)
Yu-Kai Huang, Wei-Chung Cheng, Ting-Ting Kuo, Juan-Cheng Yang, Yang-Chang Wu, Heng-Hsiung Wu, Chia-Chien Lo, Chih-Ying Hsieh, Sze-Ching Wong, Chih-Hao Lu, Wan-Ling Wu, Shih-Jen Liu, Yi-Chuan Li, Ching-Chan Lin, Chia-Ning Shen, Mien-Chie Hung, Jaw-Town Lin, Chun-Chieh Yeh, Yuh-Pyng Sher
Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. Nature cancer 5 (3) (2024)
Guang Lei, Chao Mao, Amber D Horbath, Yuelong Yan, Shirong Cai, Yao Jun, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy Anthony Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer discovery 14 (8) (2024)
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nature communications 15 (1) (2024)
Yu-Kai Huang, Wei-Chung Cheng, Ting-Ting Kuo, Juan-Cheng Yang, Yang-Chang Wu, Heng-Hsiung Wu, Chia-Chien Lo, Chih-Ying Hsieh, Sze-Ching Wong, Chih-Hao Lu, Wan-Ling Wu, Shih-Jen Liu, Yi-Chuan Li, Ching-Chan Lin, Chia-Ning Shen, Mien-Chie Hung, Jaw-Town Lin, Chun-Chieh Yeh, Yuh-Pyng Sher
Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. Nature cancer (2024)
Li-Li Feng, Shu-Ying Bie, Zhi-Heng Deng, Shao-Mei Bai, Jie Shi, Cao-Litao Qin, Huan-Lei Liu, Jia-Xu Li, Wan-Ying Chen, Jin-Ying Zhou, Chun-Mei Jiao, Yi Ma, Meng-Bo Qiu, Hua-Song Ai, Jian Zheng, Mien-Chie Hung, Yun-Long Wang, Xiang-Bo Wan, Xin-Juan Fan
Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nature communications 15 (1) (2024)
Guang Lei, Chao Mao, Amber D Horbath, Yuelong Yan, Shirong Cai, Yao Jun, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy Anthony Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers. Cancer discovery (2024)
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nature communications 15 (1) (2024)
Li-Li Feng, Shu-Ying Bie, Zhi-Heng Deng, Shao-Mei Bai, Jie Shi, Cao-Litao Qin, Huan-Lei Liu, Jia-Xu Li, Wan-Ying Chen, Jin-Ying Zhou, Chun-Mei Jiao, Yi Ma, Meng-Bo Qiu, Hua-Song Ai, Jian Zheng, Mien-Chie Hung, Yun-Long Wang, Xiang-Bo Wan, Xin-Juan Fan
Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nature communications 15 (1) (2024)
Chunxiao Liu, Chenhao Zhou, Weiya Xia, Yifan Zhou, Yufan Qiu, Jialei Weng, Qiang Zhou, Wanyong Chen, Ying-Nai Wang, Heng-Huan Lee, Shao-Chun Wang, Ming Kuang, Dihua Yu, Ning Ren, Mien-Chie Hung
Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma. Nature communications 15 (1) (2024)
Li-Li Feng, Shu-Ying Bie, Zhi-Heng Deng, Shao-Mei Bai, Jie Shi, Cao-Litao Qin, Huan-Lei Liu, Jia-Xu Li, Wan-Ying Chen, Jin-Ying Zhou, Chun-Mei Jiao, Yi Ma, Meng-Bo Qiu, Hua-Song Ai, Jian Zheng, Mien-Chie Hung, Yun-Long Wang, Xiang-Bo Wan, Xin-Juan Fan
Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Guang Lei, Chao Mao, Amber D Horbath, Yuelong Yan, Shirong Cai, Yao Jun, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy Anthony Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers. Cancer discovery (2024)
Guang Lei, Chao Mao, Amber D Horbath, Yuelong Yan, Shirong Cai, Yao Jun, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy Anthony Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer discovery 14 (8) (2024)
Li-Li Feng, Shu-Ying Bie, Zhi-Heng Deng, Shao-Mei Bai, Jie Shi, Cao-Litao Qin, Huan-Lei Liu, Jia-Xu Li, Wan-Ying Chen, Jin-Ying Zhou, Chun-Mei Jiao, Yi Ma, Meng-Bo Qiu, Hua-Song Ai, Jian Zheng, Mien-Chie Hung, Yun-Long Wang, Xiang-Bo Wan, Xin-Juan Fan
Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Yu-Kai Huang, Wei-Chung Cheng, Ting-Ting Kuo, Juan-Cheng Yang, Yang-Chang Wu, Heng-Hsiung Wu, Chia-Chien Lo, Chih-Ying Hsieh, Sze-Ching Wong, Chih-Hao Lu, Wan-Ling Wu, Shih-Jen Liu, Yi-Chuan Li, Ching-Chan Lin, Chia-Ning Shen, Mien-Chie Hung, Jaw-Town Lin, Chun-Chieh Yeh, Yuh-Pyng Sher
Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. Nature cancer (2024)
Chunxiao Liu, Chenhao Zhou, Weiya Xia, Yifan Zhou, Yufan Qiu, Jialei Weng, Qiang Zhou, Wanyong Chen, Ying-Nai Wang, Heng-Huan Lee, Shao-Chun Wang, Ming Kuang, Dihua Yu, Ning Ren, Mien-Chie Hung
Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma. Nature communications 15 (1) (2024)
Yu-Kai Huang, Wei-Chung Cheng, Ting-Ting Kuo, Juan-Cheng Yang, Yang-Chang Wu, Heng-Hsiung Wu, Chia-Chien Lo, Chih-Ying Hsieh, Sze-Ching Wong, Chih-Hao Lu, Wan-Ling Wu, Shih-Jen Liu, Yi-Chuan Li, Ching-Chan Lin, Chia-Ning Shen, Mien-Chie Hung, Jaw-Town Lin, Chun-Chieh Yeh, Yuh-Pyng Sher
Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. Nature cancer 5 (3) (2024)
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nature communications 15 (1) (2024)
Zong-Shin Lin, Chiao-Chen Chung, Yu-Chia Liu, Chu-Han Chang, Hui-Chia Liu, Yung-Yi Liang, Teng-Le Huang, Tsung-Ming Chen, Che-Hsin Lee, Chih-Hsin Tang, Mien-Chie Hung, Ya-Huey Chen
EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. eLife 12 (2023)
Ming-You Shie, Hsin-Yuan Fang, Kai-Wen Kan, Chia-Che Ho, Chih-Yen Tu, Pei-Chih Lee, Po-Ren Hsueh, Chia-Hung Chen, Alvin Kai-Xing Lee, Ni Tien, Jian-Xun Chen, Yu-Cheng Shen, Jan-Gowth Chang, Yu-Fang Shen, Ting-Ju Lin, Ben Wang, Mien-Chie Hung, Der-Yang Cho, Yi-Wen Chen
Highly Mimetic Ex Vivo Lung-Cancer Spheroid-Based Physiological Model for Clinical Precision Therapeutics. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Cheng-Cao Sun, Youqiong Ye, Zhi Tan, Yuan Liu, Yajuan Li, Wei Hu, Ke Liang, Sergey D Egranov, Lisa Angela Huang, Zhao Zhang, Yaohua Zhang, Yao Jun, Tina K Nguyen, Zilong Zhao, Andrew Wu, Jeffrey R Marks, Abigail S Caudle, Aysegul A Sahin, Jianjun Gao, Seth T Gammon, David Piwnica-Worms, Jian Hu, Paul J Chiao, Dihua Yu, Mien-Chie Hung, Michael A Curran, George A Calin, Haoqiang Ying, Leng Han, Chunru Lin, Liuqing Yang
Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Science advances 9 (5) (2023)
An Xu, Mo Liu, Mo-Fan Huang, Yang Zhang, Ruifeng Hu, Julian A Gingold, Ying Liu, Dandan Zhu, Chian-Shiu Chien, Wei-Chen Wang, Zian Liao, Fei Yuan, Chih-Wei Hsu, Jian Tu, Yao Yu, Taylor Rosen, Feng Xiong, Peilin Jia, Yi-Ping Yang, Danielle A Bazer, Ya-Wen Chen, Wenbo Li, Chad D Huff, Jay-Jiguang Zhu, Francesca Aguilo, Shih-Hwa Chiou, Nathan C Boles, Chien-Chen Lai, Mien-Chie Hung, Zhong-Ming Zhao, Eric L Van Nostrand, Ruiying Zhao, Dung-Fang Lee
Rewired m 6 A epitranscriptomic networks link mutant p53 to neoplastic transformation. Nature communications 14 (1) (2023)
Zong-Shin Lin, Chiao-Chen Chung, Yu-Chia Liu, Chu-Han Chang, Hui-Chia Liu, Yung-Yi Liang, Teng-Le Huang, Tsung-Ming Chen, Che-Hsin Lee, Chih-Hsin Tang, Mien-Chie Hung, Ya-Huey Chen
EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. eLife 12 (2023)
Zong-Shin Lin, Chiao-Chen Chung, Yu-Chia Liu, Chu-Han Chang, Hui-Chia Liu, Yung-Yi Liang, Teng-Le Huang, Tsung-Ming Chen, Che-Hsin Lee, Chih-Hsin Tang, Mien-Chie Hung, Ya-Huey Chen
EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. eLife 12 (2023)
Hsiao-Fan Chen, Wei-Jan Wang, Chung-Yu Chen, Wei-Chao Chang, Po-Ren Hsueh, Shin-Lei Peng, Chen-Shiou Wu, Yeh Chen, Hsin-Yu Huang, Wan-Jou Shen, Shao-Chun Wang, Mien-Chie Hung
The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2. eLife 12 (2023)
Cheng-Cao Sun, Youqiong Ye, Zhi Tan, Yuan Liu, Yajuan Li, Wei Hu, Ke Liang, Sergey D Egranov, Lisa Angela Huang, Zhao Zhang, Yaohua Zhang, Yao Jun, Tina K Nguyen, Zilong Zhao, Andrew Wu, Jeffrey R Marks, Abigail S Caudle, Aysegul A Sahin, Jianjun Gao, Seth T Gammon, David Piwnica-Worms, Jian Hu, Paul J Chiao, Dihua Yu, Mien-Chie Hung, Michael A Curran, George A Calin, Haoqiang Ying, Leng Han, Chunru Lin, Liuqing Yang
Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Science advances 9 (5) (2023)
Cheng-Cao Sun, Youqiong Ye, Zhi Tan, Yuan Liu, Yajuan Li, Wei Hu, Ke Liang, Sergey D Egranov, Lisa Angela Huang, Zhao Zhang, Yaohua Zhang, Yao Jun, Tina K Nguyen, Zilong Zhao, Andrew Wu, Jeffrey R Marks, Abigail S Caudle, Aysegul A Sahin, Jianjun Gao, Seth T Gammon, David Piwnica-Worms, Jian Hu, Paul J Chiao, Dihua Yu, Mien-Chie Hung, Michael A Curran, George A Calin, Haoqiang Ying, Leng Han, Chunru Lin, Liuqing Yang
Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Science advances 9 (5) (2023)
An Xu, Mo Liu, Mo-Fan Huang, Yang Zhang, Ruifeng Hu, Julian A Gingold, Ying Liu, Dandan Zhu, Chian-Shiu Chien, Wei-Chen Wang, Zian Liao, Fei Yuan, Chih-Wei Hsu, Jian Tu, Yao Yu, Taylor Rosen, Feng Xiong, Peilin Jia, Yi-Ping Yang, Danielle A Bazer, Ya-Wen Chen, Wenbo Li, Chad D Huff, Jay-Jiguang Zhu, Francesca Aguilo, Shih-Hwa Chiou, Nathan C Boles, Chien-Chen Lai, Mien-Chie Hung, Zhong-Ming Zhao, Eric L Van Nostrand, Ruiying Zhao, Dung-Fang Lee
Rewired m 6 A epitranscriptomic networks link mutant p53 to neoplastic transformation. Nature communications 14 (1) (2023)
Ming-You Shie, Hsin-Yuan Fang, Kai-Wen Kan, Chia-Che Ho, Chih-Yen Tu, Pei-Chih Lee, Po-Ren Hsueh, Chia-Hung Chen, Alvin Kai-Xing Lee, Ni Tien, Jian-Xun Chen, Yu-Cheng Shen, Jan-Gowth Chang, Yu-Fang Shen, Ting-Ju Lin, Ben Wang, Mien-Chie Hung, Der-Yang Cho, Yi-Wen Chen
Highly Mimetic Ex Vivo Lung-Cancer Spheroid-Based Physiological Model for Clinical Precision Therapeutics. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Cheng-Cao Sun, Youqiong Ye, Zhi Tan, Yuan Liu, Yajuan Li, Wei Hu, Ke Liang, Sergey D Egranov, Lisa Angela Huang, Zhao Zhang, Yaohua Zhang, Yao Jun, Tina K Nguyen, Zilong Zhao, Andrew Wu, Jeffrey R Marks, Abigail S Caudle, Aysegul A Sahin, Jianjun Gao, Seth T Gammon, David Piwnica-Worms, Jian Hu, Paul J Chiao, Dihua Yu, Mien-Chie Hung, Michael A Curran, George A Calin, Haoqiang Ying, Leng Han, Chunru Lin, Liuqing Yang
Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Science advances 9 (5) (2023)
An Xu, Mo Liu, Mo-Fan Huang, Yang Zhang, Ruifeng Hu, Julian A Gingold, Ying Liu, Dandan Zhu, Chian-Shiu Chien, Wei-Chen Wang, Zian Liao, Fei Yuan, Chih-Wei Hsu, Jian Tu, Yao Yu, Taylor Rosen, Feng Xiong, Peilin Jia, Yi-Ping Yang, Danielle A Bazer, Ya-Wen Chen, Wenbo Li, Chad D Huff, Jay-Jiguang Zhu, Francesca Aguilo, Shih-Hwa Chiou, Nathan C Boles, Chien-Chen Lai, Mien-Chie Hung, Zhong-Ming Zhao, Eric L Van Nostrand, Ruiying Zhao, Dung-Fang Lee
Rewired m 6 A epitranscriptomic networks link mutant p53 to neoplastic transformation. Nature communications 14 (1) (2023)
Zong-Shin Lin, Chiao-Chen Chung, Yu-Chia Liu, Chu-Han Chang, Hui-Chia Liu, Yung-Yi Liang, Teng-Le Huang, Tsung-Ming Chen, Che-Hsin Lee, Chih-Hsin Tang, Mien-Chie Hung, Ya-Huey Chen
EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. eLife 12 (2023)
Cheng-Cao Sun, Youqiong Ye, Zhi Tan, Yuan Liu, Yajuan Li, Wei Hu, Ke Liang, Sergey D Egranov, Lisa Angela Huang, Zhao Zhang, Yaohua Zhang, Yao Jun, Tina K Nguyen, Zilong Zhao, Andrew Wu, Jeffrey R Marks, Abigail S Caudle, Aysegul A Sahin, Jianjun Gao, Seth T Gammon, David Piwnica-Worms, Jian Hu, Paul J Chiao, Dihua Yu, Mien-Chie Hung, Michael A Curran, George A Calin, Haoqiang Ying, Leng Han, Chunru Lin, Liuqing Yang
Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Science advances 9 (5) (2023)
Chen-Shiou Wu, Yi-Chuan Li, Shin-Lei Peng, Chung-Yu Chen, Hsiao-Fan Chen, Po-Ren Hsueh, Wei-Jan Wang, Yen-Yi Liu, Ciao-Ling Jiang, Wei-Chao Chang, Shao-Chun Wang, Mien-Chie Hung
Coffee as a dietary strategy to prevent SARS-CoV-2 infection. Cell & bioscience 13 (1) (2023)
Ming-You Shie, Hsin-Yuan Fang, Kai-Wen Kan, Chia-Che Ho, Chih-Yen Tu, Pei-Chih Lee, Po-Ren Hsueh, Chia-Hung Chen, Alvin Kai-Xing Lee, Ni Tien, Jian-Xun Chen, Yu-Cheng Shen, Jan-Gowth Chang, Yu-Fang Shen, Ting-Ju Lin, Ben Wang, Mien-Chie Hung, Der-Yang Cho, Yi-Wen Chen
Highly Mimetic Ex Vivo Lung-Cancer Spheroid-Based Physiological Model for Clinical Precision Therapeutics. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Ming-You Shie, Hsin-Yuan Fang, Kai-Wen Kan, Chia-Che Ho, Chih-Yen Tu, Pei-Chih Lee, Po-Ren Hsueh, Chia-Hung Chen, Alvin Kai-Xing Lee, Ni Tien, Jian-Xun Chen, Yu-Cheng Shen, Jan-Gowth Chang, Yu-Fang Shen, Ting-Ju Lin, Ben Wang, Mien-Chie Hung, Der-Yang Cho, Yi-Wen Chen
Highly Mimetic Ex Vivo Lung-Cancer Spheroid-Based Physiological Model for Clinical Precision Therapeutics. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Zong-Shin Lin, Chiao-Chen Chung, Yu-Chia Liu, Chu-Han Chang, Hui-Chia Liu, Yung-Yi Liang, Teng-Le Huang, Tsung-Ming Chen, Che-Hsin Lee, Chih-Hsin Tang, Mien-Chie Hung, Ya-Huey Chen
EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. eLife 12 (2023)
Wei-Jan Wang, Yeh Chen, Wen-Chi Su, Yen-Yi Liu, Wan-Jou Shen, Wei-Chao Chang, Sheng-Teng Huang, Cheng-Wen Lin, Yu-Chuan Wang, Chia-Shin Yang, Mei-Hui Hou, Yu-Chi Chou, Yang-Chang Wu, Shao-Chun Wang, Mien-Chie Hung
Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2. Journal of food biochemistry 46 (10) (2022)
Yu-Yi Chu, Clinton Yam, Hirohito Yamaguchi, Mien-Chie Hung
Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors. Journal of biomedical science 29 (1) (2022)
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Li-Li Feng, Shu-Ying Bie, Li Gong, Fang Wang, Ming-Biao Wei, Wei-Xing Feng, Xiao-Lin Pang, Cao-Litao Qin, Xin-Ke Yin, Ying-Nai Wang, Weihua Zhou, Daniel R Wahl, Quentin Liu, Ming Chen, Mien-Chie Hung, Xiang-Bo Wan
MRNIP condensates promote DNA double-strand break sensing and end resection. Nature communications 13 (1) (2022)
Yaohua Zhang, Cheng-Cao Sun, Yajuan Li, Juan Qin, Kaushik Amancherla, Ying Jing, Qingsong Hu, Ke Liang, Zhao Zhang, Youqiong Ye, Lisa A Huang, Tina K Nguyen, Sergey D Egranov, Zilong Zhao, Andrew Wu, Yutao Xi, Yao Jun, Mien-Chie Hung, George A Calin, Jie Cheng, Bora Lim, Lorenz H Lehmann, Joe-Elie Salem, Douglas B Johnson, Michael A Curran, Dihua Yu, Leng Han, Radbod Darabi, Liuqing Yang, Javid J Moslehi, Chunru Lin
Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Science translational medicine 14 (669) (2022)
Xixi Zhao, Yongkun Wei, Yu-Yi Chu, Yintao Li, Jung-Mao Hsu, Zhou Jiang, Chunxiao Liu, Jennifer L Hsu, Wei-Chao Chang, Ri-Yao Yang, Li-Chuan Chan, Jingkun Qu, Shuqun Zhang, Haoqiang Ying, Dihua Yu, Mien-Chie Hung
Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function. Cancer research 82 (11) (2022)
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Yan Ma, Xin-Ke Yin, Li-Li Feng, Guang-Dong Zeng, Fang Wang, Wei-Xing Feng, Jian Zheng, Ying-Nai Wang, Bing Zeng, Quentin Liu, Mien-Chie Hung, Xiang-Bo Wan
DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0. Cell death & disease 13 (8) (2022)
Yu-Yi Chu, Mei-Kuang Chen, Yongkun Wei, Heng-Huan Lee, Weiya Xia, Ying-Nai Wang, Clinton Yam, Jennifer L Hsu, Hung-Ling Wang, Wei-Chao Chang, Hirohito Yamaguchi, Zhou Jiang, Chunxiao Liu, Ching-Fei Li, Lei Nie, Li-Chuan Chan, Yuan Gao, Shao-Chun Wang, Jinsong Liu, Shannon Neville Westin, Sanghoon Lee, Anil K Sood, Liuqing Yang, Gabriel N Hortobagyi, Dihua Yu, Mien-Chie Hung
Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex. Nature cancer 3 (10) (2022)
Hirohito Yamaguchi, Jung-Mao Hsu, Wen-Hao Yang, Mien-Chie Hung
Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics. Nature reviews. Clinical oncology 19 (5) (2022)
Rodney Cheng-En Hsieh, Krishnan Sunil, Ren-Chin Wu, Akash R Boda, Arthur J Liu, Michelle Winkler, Wen-Hao Hsu, Steven Hsesheng Lin, Mien-Chie Hung, Li-Chuan Chan, Krithikaa Rajkumar Bhanu, Anupallavi Srinivasamani, Ricardo Alexandre De Azevedo, Yung-Chih Chou, Ronald A DePinho, Matthew M Gubin, Eduardo Vilar, Chao-Hsien Chen, Ravaen Slay, Priyamvada Jayaprakash, Shweta Mahendra Hegde, Genevieve Hartley, Spencer Thomas Lea, Rishika Prasad, Brittany Morrow, Coline Agnes Couillault, Madeline Steiner, Chun-Chieh Wang, Bhanu Prasad Venkatesulu, Cullen M Taniguchi, Yon Son Betty Kim, Junjie Chen, Nils-Petter Rudqvist, Michael A Curran
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer. Science immunology 7 (72) (2022)
Xin-Ke Yin, Yun-Long Wang, Fei Wang, Wei-Xing Feng, Shao-Mei Bai, Wan-Wen Zhao, Li-Li Feng, Ming-Biao Wei, Cao-Litao Qin, Fang Wang, Zhi-Li Chen, Hong-Jun Yi, Yan Huang, Pei-Yi Xie, Taewan Kim, Ying-Nai Wang, Jun-Wei Hou, Chia-Wei Li, Quentin Liu, Xin-Juan Fan, Mien-Chie Hung, Xiang-Bo Wan
PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer. Oncogene 40 (7) (2021)
Lin Zhang, Yao Jun, Yongkun Wei, Zhifen Zhou, Ping Li, Jingkun Qu, Akosua Badu-Nkansah, Xiangliang Yuan, Yu-Wen Huang, Kazutaka Fukumura, Xizeng Mao, Wei-Chao Chang, Jodi Marie Saunus, Sunil R Lakhani, Jason T Huse, Mien-Chie Hung, Dihua Yu
Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases. Science translational medicine 12 (545) (2021)
Yufan Qiu, Yi Yang, Ri-Yao Yang, Chunxiao Liu, Jung-Mao Hsu, Zhou Jiang, Linlin Sun, Yongkun Wei, Chia-Wei Li, Dihua Yu, Jin Zhang, Mien-Chie Hung
Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer. Oncogene 40 (31) (2021)
Ri-Yao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Jun Yao, Hui Li, Meisi Yan, Wei-Chao Chang, Jung-Mao Hsu, Jong-Ho Cha, Jennifer L Hsu, Cheng-Wei Chou, Xian Sun, Yalan Deng, Chao-Kai Chou, Dihua Yu, Mien-Chie Hung
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. Nature communications 12 (1) (2021)
Heng-Huan Lee, Ying-Nai Wang, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Yu-Han Wang, Zhou Jiang, Shouping Xu, Jun Yao, Yufan Qiu, Yi-Hsin Hsu, Wei-Lun Hwang, Meisi Yan, Jong-Ho Cha, Jennifer L Hsu, Jia Shen, Yuanqing Ye, Xifeng Wu, Ming-Feng Hou, Lin-Ming Tseng, Shao-Chun Wang, Mei-Ren Pan, Chin-Hua Yang, Yuan-Liang Wang, Hirohito Yamaguchi, Da Pang, Gabriel N Hortobagyi, Dihua Yu, Mien-Chie Hung
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nature communications 12 (1) (2021)
Chia-Hung Chen, Bo-Wei Wang, Yu-Chun Hsiao, Chun-Yi Wu, Fang-Ju Cheng, Te-Chun Hsia, Chih-Yi Chen, Yihua Wang, Zhang Weihua, Ruey-Hwang Chou, Chih-Hsin Tang, Yun-Ju Chen, Ya-Ling Wei, Jennifer L Hsu, Wen-Chien Cheng, Mien-Chie Hung, Wei-Chien Huang
PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs. Oncogene 40 (29) (2021)
Jinquan Liu, Bo Yuan, Jin Cao, Hongjie Luo, Shuchen Gu, Mengdi Zhang, Ran Ding, Long Zhang, Fangfang Zhou, Mien-Chie Hung, Ping-Long Xu, Xia Lin, Jianping Jin, Xin-Hua Feng
AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4. Cancer research 81 (19) (2021)
Yalan Deng, Xianghou Xia, Yang Zhao, Zilong Zhao, Consuelo Martinez, Wenjuan Yin, Jun Yao, Qinglei Hang, Weiche Wu, Jie Zhang, Yang Yu, Weiya Xia, Fan Yao, Di Zhao, Yutong Sun, Haoqiang Ying, Mien-Chie Hung, Li Ma
Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. Nature communications 12 (1) (2021)
Yajuan Li, Zhi Tan, Yaohua Zhang, Zhao Zhang, Qingsong Hu, Ke Liang, Yao Jun, Youqiong Ye, Yi-Chuan Li, Chunlai Li, Lan Liao, Jianming Xu, Zhen Xing, Yinghong Pan, Sujash S Chatterjee, Tina K Nguyen, Heidi Hsiao, Sergey D Egranov, Nagireddy Putluri, Cristian Coarfa, David H Hawke, Preethi H Gunaratne, Kuang-Lei Tsai, Leng Han, Mien-Chie Hung, George A Calin, Fares Namour, Jean-Louis Guéant, Ania Carolina Muntau, Nenad Blau, Vernon Reid Sutton, Manuel Schiff, François Feillet, Shuxing Zhang, Chunru Lin, Liuqing Yang
A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science (New York, N.Y.) 373 (6555) (2021)
Fang-Ju Cheng, Chia-Hung Chen, Wen-Chen Tsai, Bo-Wei Wang, Meng-Chieh Yu, Te-Chun Hsia, Ya-Ling Wei, Yu-Chun Hsiao, Dai-Wei Hu, Chien-Yi Ho, Tzong-Shiun Li, Chun-Yi Wu, Wen-Yu Chou, Han-Chung Lee, Chih-Hsin Tang, Chih-Yi Chen, Chuan-Mu Chen, Jennifer L Hsu, Hsiao-Fan Chen, Yeh Chen, Wen-Chien Cheng, Mien-Chie Hung, Wei-Chien Huang
Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC. Oncogene 40 (6) (2020)
Ying-Nai Wang, Heng-Huan Lee, Jennifer L Hsu, Dihua Yu, Mien-Chie Hung
The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis. Journal of biomedical science 27 (1) (2020)
Xinxin Song, Zhuan Zhou, Hongchun Li, Yifan Xue, Xinghua Lu, Ivet Bahar, Oliver Kepp, Mien-Chie Hung, Guido Kroemer, Yong Wan
Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers. Cancer discovery 10 (12) (2020)
Yaohua Zhang, Yajuan Li, Qingsong Hu, Yutao Xi, Zhen Xing, Zhao Zhang, Lisa Huang, Jianbo Wu, Ke Liang, Tina K Nguyen, Sergey D Egranov, Chengcao Sun, Zilong Zhao, David H Hawke, Jin Li, Deqiang Sun, Jean J Kim, Ping Zhang, Jie Cheng, Abid Farida, Mien-Chie Hung, Leng Han, Radbod Darabi, Chunru Lin, Liuqing Yang
The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nature cell biology 22 (11) (2020)
Linlin Sun, Chia-Wei Li, Ezra M Chung, Ri-Yao Yang, Yong-Soo Kim, Andrew H Park, Yun-Ju Lai, Yu-Han Wang, Jielin Liu, Yufan Qiu, Kay-Hooi Khoo, Jun Yao, Jennifer L Hsu, Jong-Ho Cha, Li-Chuan Chan, Jung-Mao Hsu, Heng-Huan Lee, Stephen S Yoo, Mien-Chie Hung
Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity. Cancer research 80 (11) (2020)
Junwei Hou, Rongce Zhao, Weiya Xia, Chiung-Wen Chang, Yun You, Jung-Mao Hsu, Lei Nie, Yeh Chen, Yu-Chuan Wang, Chunxiao Liu, Wei-Jan Wang, Yun Wu, Baozhen Ke, Jennifer L Hsu, Kebin Huang, Zu Ye, Yi Yang, Xianghou Xia, Yintao Li, Chia-Wei Li, Bin Shao, John A Tainer, Mien-Chie Hung
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nature cell biology 22 (10) (2020)
Fei-Yun Chen, Min-Yu Huang, Yu-Min Lin, Chi-Huan Ho, Shu-Yu Lin, Hsin-Yi Chen, Mien-Chie Hung, Ruey-Hwa Chen
BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. The Journal of cell biology 218 (9) (2019)
Liran Zhou, Hongmei Husted, Todd Moore, Mason Lu, Defeng Deng, Yan Liu, Vijaya Ramachandran, Thiruvengadam Arumugam, Christof Niehrs, Huamin Wang, Paul Chiao, Jianhua Ling, Michael A Curran, Anirban Maitra, Mien-Chie Hung, Jeffrey E Lee, Craig D Logsdon, Rosa F Hwang
Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma. Science translational medicine 10 (464) (2019)
Nan Li, Yifan Wang, Shinya Neri, Yuanli Zhen, Lon Wolf R Fong, Yawei Qiao, Xu Li, Zhen Chen, Clifford Stephen, Weiye Deng, Rui Ye, Wen Jiang, Shuxing Zhang, Yonghao Yu, Mien-Chie Hung, Junjie Chen, Steven H Lin
Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nature communications 10 (1) (2019)
Peng Wang, Ying Gong, Tao Guo, Man Li, Lei Fang, Shengchen Yin, Muhammad Kamran, Yang Liu, Jie Xu, Lingzhi Xu, Fei Peng, Xiaoyuan Xue, Mengying Yang, Mien-Chie Hung, Eric Wing-Fai Lam, Chundong Gu, Chunli Wang, Qimin Zhan, Quentin Liu
Activation of Aurora A kinase increases YAP stability via blockage of autophagy. Cell death & disease 10 (6) (2019)
Monique B Nilsson, Huiying Sun, Lixia Diao, Pan Tong, Diane Liu, Lerong Li, Youhong Fan, Alissa Poteete, Seung-Oe Lim, Kathryn Howells, Vincent Haddad, Daniel Gomez, Hai Tran, Guillermo Armaiz Pena, Lecia V Sequist, James Chih-Hsin Yang, Jing Wang, Edward S Kim, Roy Herbst, Jiun-Kae Jack Lee, Waun Ki Hong, Ignacio I Wistuba, Mien-Chie Hung, Anil K Sood, John Victor Heymach
Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers. Science translational medicine 9 (415) (2018)
Ying-Nai Wang, Heng-Huan Lee, Mien-Chie Hung
A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases. Journal of biomedical science 25 (1) (2018)

Mien-Chie Hung (Mie-Chie Hung)

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