Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD.
Kristoffer K OstridgeNicholas P WilliamsViktoriya KimStephen HardenSimon BourneStuart C ClarkeEmmanuel ArisSonia Mesia-VelaJeanne-Marie DevasterAndrew TuckAnthony WilliamsStephen WoottonKarl J StaplesTom M A Wilkinsonnull nullPublished in: Respiratory research (2018)
This study provides further validation for the use of quantitative CT measures of emphysema and small airways disease in COPD as they showed strong associations with pulmonary physiology and functional status. In contrast to this quantitative CT measures showed few convincing associations with biological measures of disease, suggesting it is not an effective tool at measuring disease activity.
Keyphrases
- chronic obstructive pulmonary disease
- disease activity
- lung function
- contrast enhanced
- computed tomography
- image quality
- cystic fibrosis
- dual energy
- systemic lupus erythematosus
- rheumatoid arthritis patients
- ankylosing spondylitis
- magnetic resonance imaging
- high resolution
- magnetic resonance
- positron emission tomography
- oxidative stress
- air pollution
- mass spectrometry
- pulmonary fibrosis