Lower or higher oxygenation targets for acute Hypoxaemic respiratory failure: Protocol for an individual patient data meta-analysis.
Frederik Mølgaard NielsenThomas Lass KlitgaardNiels Henrik BruunMorten Hylander MöllerOlav Lilleholt SchjørringBodil Steen RasmussenPublished in: Acta anaesthesiologica Scandinavica (2023)
The presented individual patient data meta-analysis will synthesise individual level patient data from two of the largest randomised clinical trials on targeted oxygen therapy in intensive care. The results will provide a re-analysis of the intervention effects on the pooled intention-to-treat populations and facilitate subgroup analyses with an increased power to detect clinically important effect modifications.
Keyphrases
- respiratory failure
- systematic review
- clinical trial
- case report
- extracorporeal membrane oxygenation
- electronic health record
- randomized controlled trial
- big data
- meta analyses
- mechanical ventilation
- open label
- liver failure
- stem cells
- study protocol
- machine learning
- bone marrow
- drug induced
- acute respiratory distress syndrome
- case control
- mesenchymal stem cells
- cell therapy