Effects of Ginsenoside Rg3 on Inhibiting Differentiation, Adipogenesis, and ER Stress-Mediated Cell Death in Brown Adipocytes.

Seung-Nam KimDae Hee KimHyuek Jong LeeJoon Seo LimJu-Hee LeeSung Yun ParkYoung Jun Koh

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

Our results demonstrate that Rg3 is able to selectively exert cytotoxicity in differentiated MPBAs while leaving undifferentiated MPBAs intact, resulting in the induction of ER stress and subsequent cell death in MPBAs via regulation of various genes related to adipocyte differentiation, adipogenesis, lipolysis, and inflammation. These results indicate that further studies on the potential therapeutic applications of Rg3 are warranted.

Keyphrases

cell death
adipose tissue
high fat diet induced
cell cycle arrest
insulin resistance
oxidative stress
genome wide
signaling pathway
fatty acid
gene expression
skeletal muscle
type diabetes
bioinformatics analysis
drug induced
cell proliferation
genome wide identification
genome wide analysis