Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis.

Thomas E MahanChao WangXin BaoAnkit ChoudhuryJason D UlrichDavid M Holtzman

Published in: Molecular neurodegeneration (2022)

This study reveals an important role of astrocytic apoE3 and apoE4 on the deposition and accumulation of Aβ plaques as well as on certain Aβ-associated downstream effects.

Keyphrases

cognitive decline
high fat diet
mouse model
mild cognitive impairment
coronary artery disease
type diabetes
multiple myeloma