Anakinra usage in febrile infection related epilepsy syndrome: an international cohort.
Yi-Chen LaiEyal MuscalElizabeth WellsNikita ShuklaKrista EschbachKi Hyeong LeeMarios KaliakatsosNevedita DesaiRonny WickströmMaurizio ViriElena FreriTiziana GranataSrishti NangiaRobertino DilenaAndreas BrunklausMark S WainwrightMark P GormanCoral M StrednyAbdurhman AsiriKhalid HundallahAsif DojaEric PayneElaine WirrellSookyong KohJessica L CarpenterJames RivielloPublished in: Annals of clinical and translational neurology (2020)
Febrile-infection related epilepsy syndrome (FIRES) is a devastating neurological condition characterized by a febrile illness preceding new onset refractory status epilepticus (NORSE). Increasing evidence suggests innate immune dysfunction as a potential pathological mechanism. We report an international retrospective cohort of 25 children treated with anakinra, a recombinant interleukin-1 receptor antagonist, as an immunomodulator for FIRES. Anakinra was potentially safe with only one child discontinuing therapy due to infection. Earlier anakinra initiation was associated with shorter duration of mechanical ventilation, ICU and hospital length of stay. Our retrospective data lay the groundwork for prospective consensus-driven cohort studies of anakinra in FIRES.
Keyphrases
- mechanical ventilation
- intensive care unit
- innate immune
- urinary tract infection
- acute respiratory distress syndrome
- cross sectional
- young adults
- mental health
- oxidative stress
- chemotherapy induced
- electronic health record
- machine learning
- stem cells
- respiratory failure
- big data
- mesenchymal stem cells
- clinical practice
- newly diagnosed
- subarachnoid hemorrhage
- replacement therapy