Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair.

Cong LanNian CaoCaiyu ChenShuang QuChao FanHao LuoAndi ZengCheng YuYuanzheng XueHongmei RenLiangpeng LiHongyong WangPedro A JoseZaicheng XuChunyu Zeng

Published in: Cell proliferation (2020)

Our data uncover a role of circulating progesterone withdrawal as a novel mechanism for the postnatal loss of mammalian cardiac regenerative potential. Progesterone promotes both neonatal and adult cardiomyocyte proliferation by up-regulating YAP expression.

Keyphrases

estrogen receptor
signaling pathway
left ventricular
stem cells
poor prognosis
mesenchymal stem cells
preterm infants
cell therapy
electronic health record
heart failure
big data
high glucose
risk assessment
bone marrow
endothelial cells
climate change
deep learning