Transcriptional Response of Multidrug-Resistant Klebsiella pneumoniae Clinical Isolates to Ciprofloxacin Stress.
Roman Farooq AlviBilal AslamMuhammad Hidayat RasoolSaima MuzammilAbu Baker SiddiqueNafeesa YasmeenMohsin KhurshidNoreen SarwarAhmad Abdulaziz A AlmatroudiRiaz HussainZulqarnain BalochPublished in: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale (2021)
The transcriptional response revealed the upregulation of DNA repair and protein folding elements (mutS and euTu) in ciprofloxacin stress and delayed cell division. The ciprofloxacin was found to trigger various stress responses in a time- and concentration-dependent manner.
Keyphrases
- multidrug resistant
- klebsiella pneumoniae
- dna repair
- pseudomonas aeruginosa
- single cell
- drug resistant
- dna damage
- acinetobacter baumannii
- gram negative
- escherichia coli
- gene expression
- transcription factor
- stress induced
- poor prognosis
- cell proliferation
- cystic fibrosis
- cell therapy
- heat shock
- molecular dynamics simulations
- bone marrow
- heat stress
- binding protein
- protein protein
- amino acid