Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation.
Pan LiaoYi HeFangyuan YangGuihu LuoJian ZhuangZeqing ZhaiLili ZhuangZhuomiao LinJiehuang ZhengErwei SunPublished in: Arthritis research & therapy (2018)
PD treatment inhibited ROS-mediated NET formation and ameliorated lupus manifestations in both PIL mice and MRL/lpr mice. These results highlight the involvement of NETosis in SLE pathogenesis and reveal that PD might be a potential therapeutic agent for SLE or other autoimmune diseases.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- high fat diet induced
- juvenile idiopathic arthritis
- cell death
- dna damage
- reactive oxygen species
- mouse model
- genome wide
- wild type
- metabolic syndrome
- dna methylation
- gene expression
- combination therapy