Clinical Outcomes in Children With Human Immunodeficiency Virus Treated for Nonsevere Tuberculosis in the SHINE Trial.
Chishala ChabalaEric WobudeyaMarieke M van der ZalmMonica KapasaPriyanka RaichurRobert MboiziMegan PalmerAarti Avinash KinikarSyed HissarVeronica MulengaVidya MavePhilippa MusokeAnneke C HesselingHelen M McIlleronDiana M GibbAngela CrookAnna Turkovanull nullPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
We found no evidence of a difference in TB outcomes between 4 and 6 months of treatment for CWH treated for nonsevere TB. Irrespective of TB treatment duration, CWH had higher rates of mortality and hospitalization than their counterparts without HIV. Clinical Trials Registration. ISRCTN63579542.
Keyphrases
- human immunodeficiency virus
- mycobacterium tuberculosis
- clinical trial
- antiretroviral therapy
- hepatitis c virus
- hiv infected
- hiv aids
- hiv positive
- young adults
- randomized controlled trial
- emergency department
- phase ii
- cardiovascular events
- cardiovascular disease
- pulmonary tuberculosis
- phase iii
- skeletal muscle
- south africa
- combination therapy
- placebo controlled
- double blind
- drug induced