Addressing Residual Disease in HER2-Positive and Triple-Negative Breast Cancer: What Is Next?
Ilana SchlamJoshua DowerFilipa C LyncePublished in: Current oncology reports (2024)
There has been a shift towards neoadjuvant systemic therapy for selected patients with HER2-positive and TNBC. Assessing the tumor's response to therapy provides prognostic information and allows individualization of the postoperative treatment for these patients based on the tumor response to neoadjuvant therapy. Patients with TNBC with residual disease after neoadjuvant therapy can be treated with pembrolizumab, capecitabine, or olaparib. Those with HER2-positive disease are treated with adjuvant trastuzumab emtansine. The treatment of early breast cancer has evolved significantly, and patient outcomes continue to improve. As better treatments are developed, we will need biomarkers to determine which patients may benefit from certain therapies to continue to improve outcomes by right-sizing treatments and limiting toxicities.
Keyphrases
- newly diagnosed
- end stage renal disease
- rectal cancer
- locally advanced
- ejection fraction
- lymph node
- peritoneal dialysis
- squamous cell carcinoma
- early stage
- stem cells
- type diabetes
- randomized controlled trial
- bone marrow
- replacement therapy
- combination therapy
- weight loss
- social media
- advanced non small cell lung cancer
- phase ii study
- cell therapy
- patient reported