Crocin Treatment after Maternal Hypoxia Attenuates Spatial Memory Impairment and Expression of BACE1 and HIF-1α in Rat Offspring Brain.

Fahimeh Fahimi Truski Zohreh Ghotbeddin Mohammad Reza Tabandeh Mahdi Pourmahdi Borujeni

Published in: Basic and clinical neuroscience (2020)

According to our results, down-regulation of HIF-1α and BACE1 gene expressions in the brain of rat offspring after crocin treatment can be suggested as a molecular mechanism for crocin to improve spatial memory.

Keyphrases

endothelial cells
oxidative stress
high fat diet
white matter
poor prognosis
working memory
resting state
pregnant women
multiple sclerosis
functional connectivity
genome wide
physical activity
transcription factor
long non coding rna
body mass index
weight gain
birth weight