One-Year Longitudinal Assessment of Patients With CMT1A Using Quantitative MRI.
Etienne FortanierMarc Adrien HostinConstance MichelEmilien DelmontMarc-Emmanuel BellemareMaxime GuyeDavid BendahanShahram AttarianPublished in: Neurology (2024)
Our results further support that qMRI is a promising tool for following up longitudinal changes in CMT1A patients, FF being the paramount MRI metric for both thigh and leg regions. It is crucial to scrutinize the postimaging data extraction methods considering that annual changes are minimal (around +1.5%). Given the varied FF distribution, the existence of a length-dependent gradient, and the differential fatty involution across muscles, 3D volume analysis appeared more suitable than single slice analysis.
Keyphrases
- magnetic resonance imaging
- end stage renal disease
- contrast enhanced
- ejection fraction
- newly diagnosed
- chronic kidney disease
- high resolution
- cross sectional
- computed tomography
- magnetic resonance
- peritoneal dialysis
- prognostic factors
- diffusion weighted imaging
- electronic health record
- patient reported outcomes
- deep learning
- soft tissue