Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression.
Gayathri SundaramChai K LimBruce J BrewGilles J GuilleminPublished in: Journal of neuroinflammation (2020)
These results provide a new mechanistic link between neuroinflammation and neurodegeneration and point to KP modulation at the KMO level to preserve immune tolerance and limit neurodegeneration in EAE. They provide the foundation for new clinical trials for MS.