Probiotics: Protecting Our Health from the Gut.
Gael Urait Varela-TrinidadCarolina Domínguez-DíazKarla Solórzano-CastanedoLiliana Íñiguez-GutiérrezTeresita de Jesús Hernández-FloresMary Fafutis MorrisPublished in: Microorganisms (2022)
The gut microbiota (GM) comprises billions of microorganisms in the human gastrointestinal tract. This microbial community exerts numerous physiological functions. Prominent among these functions is the effect on host immunity through the uptake of nutrients that strengthen intestinal cells and cells involved in the immune response. The physiological functions of the GM are not limited to the gut, but bidirectional interactions between the gut microbiota and various extraintestinal organs have been identified. These interactions have been termed interorganic axes by several authors, among which the gut-brain, gut-skin, gut-lung, gut-heart, and gut-metabolism axes stand out. It has been shown that an organism is healthy or in homeostasis when the GM is in balance. However, altered GM or dysbiosis represents a critical factor in the pathogenesis of many local and systemic diseases. Therefore, probiotics intervene in this context, which, according to various published studies, allows balance to be maintained in the GM, leading to an individual's good health.
Keyphrases
- microbial community
- induced apoptosis
- immune response
- public health
- healthcare
- mental health
- endothelial cells
- heart failure
- randomized controlled trial
- oxidative stress
- risk assessment
- white matter
- multiple sclerosis
- brain injury
- toll like receptor
- cell proliferation
- social media
- inflammatory response
- functional connectivity
- heavy metals
- antibiotic resistance genes
- dendritic cells
- blood brain barrier
- subarachnoid hemorrhage