The interaction of insoluble Amyloid-β with soluble Amyloid-β dimers decreases Amyloid-β plaque numbers.
Else F van GerresheimArne HerringLothar GremerAndreas Müller-SchiffmannKathy KeyvaniCarsten KorthPublished in: Neuropathology and applied neurobiology (2021)
Our study indicates that Aβ dimers directly interfere with Aβ fibril formation in vivo and in vitro. The variable interaction of Aβ dimers with insoluble Aβ seeds could thus contribute to the heterogeneity of Aβ plaque load in AD patients.