Overexpression of splicing factor poly(rC)-binding protein 1 elicits cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells.

Yuhong ChenZhihui DouXiaohua ChenDapeng ZhaoTuanjie CheWei SuTao QuTaotao ZhangCaipeng XuHuiweng LeiQiang LiHong ZhangCuixia Di

Published in: Journal of cancer research and clinical oncology (2022)

Our results revealed that PCBP1 played a vital role in p73 splicing, cycle arrest and apoptosis induction in human cervical carcinoma cells. Targeting PCBP1 may be a potential therapeutic strategy for cervical cancer therapy.

Keyphrases

cancer therapy
endothelial cells
oxidative stress
endoplasmic reticulum stress
binding protein
induced pluripotent stem cells
cell cycle arrest
cell cycle
cell death
drug delivery
pluripotent stem cells
single cell
pi k akt