Whole-Genome Sequencing of Common Salivary Gland Carcinomas: Subtype-Restricted and Shared Genetic Alterations.

Tatiana V KarpinetsYoshitsugu Mitani Bin LiuJianhua ZhangKristen B PytyniaLinton D SellenDanice T KaragiannisRenata FerrarottoAndrew P FutrealAdel K El-Naggar

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

This study delineates type-specific and shared genetic alterations that are associated with early phenotypic commitment and the biologic progression of common SGCs. These alterations, upon validation, could serve as biomarkers in tumor-specific clinical trials.

Keyphrases

clinical trial
genome wide
rheumatoid arthritis
copy number
randomized controlled trial
high grade
cell fate