Protein Identification for Stroke Progression via Mendelian Randomization in Million Veteran Program and UK Biobank.

Andrew R ElmoreNimish AdhikariApril E HartleyHugo Javier AparicioDaniel C PosnerGibran HemaniKate TillingTom R GauntPeter W F WilsonJuan P CasasJohn Michael GazianoGeorge Davey SmithLavinia PaternosterKelly ChoGina M Peloso

Published in: Stroke (2024)

We found evidence that 2 proteins with little effect on incident stroke appear to influence subsequent MACE after incident AIS. These associations suggest that inflammation is a contributing factor to subsequent MACE outcomes after incident AIS and highlights potential novel targets.

Keyphrases

cardiovascular disease
atrial fibrillation
oxidative stress
quality improvement
cross sectional
amino acid
risk assessment
cerebral ischemia
human health
protein protein
binding protein
blood brain barrier