Integrative analysis identifies genetic variant modulating MICA expression and altering susceptibility to persistent HBV infection.

Yajie GongXiang ChengJianbo TianJiaoyuan LiYing ZhuYang YangDanyi ZouXiating PengJinzhuo LuoLei ZhaoShufang MeiXiaoyang WangNan YangJuntao KeJing GongJiang ChangYing WangRong Zhong

Published in: Liver international : official journal of the International Association for the Study of the Liver (2019)

Our findings suggest that the germline G > A variation at rs2523454 may influence TF-DNA interaction, downregulate the expression of MICA and play an important role in the development of persistent HBV infection in the Chinese population.

Keyphrases

poor prognosis
hepatitis b virus
genome wide
liver failure
gene expression
single molecule
cell free
dna repair
dna damage