Liriogerphines A-D, a Class of Sesquiterpene-Alkaloid Hybrids from the Rare Chinese Tulip Tree Plant.
Yu-Hang HeQi-Xiu LiYu-Fei WuChun-Xiao JiangQi ZhouZe-Xin JinWen-Xue ChenYi-Cheng MaoJin-Feng HuJuan XiongPublished in: The Journal of organic chemistry (2022)
Liriogerphines A-D ( 1-4 , respectively), an unprecedented class of hybrids of germacranolide-type sesquiterpenoids and aporphine-type alkaloids, were isolated from the rare medicinal plant Liriodendron chinense . Their structures were elucidated by comprehensive spectroscopic analyses combined with electronic circular dichroism calculations and X-ray crystallographic data. Biosynthetically, an aza-Michael addition reaction is proposed to be involved in the assemblies of this class of hybrids. Compound 4 exhibited cytotoxicity against leukemia cells via inducing apoptosis and inhibiting Bcl-2 expression.
Keyphrases
- cell cycle arrest
- induced apoptosis
- high resolution
- endoplasmic reticulum stress
- cell death
- poor prognosis
- oxidative stress
- signaling pathway
- acute myeloid leukemia
- molecular docking
- bone marrow
- electronic health record
- molecular dynamics
- molecular dynamics simulations
- big data
- machine learning
- magnetic resonance
- cell wall
- computed tomography
- deep learning
- cell proliferation
- dual energy
- contrast enhanced