Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression.
Jiayu YeJohn M BaerDouglas V FagetVasilios A MorikisQihao RenAnupama MelamAna Paula DelgadoXianmin LuoSatarupa Mullick BagchiJad I BelleEdward CamposMichael FriedmanDeborah J VeisErik S KnudsenAgnieszka K WitkiewiczScott PowersGregory D LongmoreDavid G DeNardoSheila A StewartPublished in: Cancer discovery (2024)
senCAFs limit NK cell-mediated killing, thereby contributing to breast cancer progression. Thus, targeting senCAFs could be a clinically viable approach to limit tumor progression.
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