Liquid biopsy of cerebrospinal fluid enables selective profiling of glioma molecular subtypes at first clinical presentation.

Francesca Orzan Francesca De Bacco Elisabetta Lazzarini Giovanni Crisafulli Alessandra Gasparini Angelo Dipasquale Ludovic Barault Marco Macagno Pasquale Persico Federico Pessina Beatrice Claudia Bono Laura Giordano Pietro Zeppa Antonio Melcarne Paola Cassoni Diego Garbossa Armando Santoro Paolo Maria Comoglio Stefano Indraccolo Matteo Simonelli Carla Boccaccio

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

This study shows potentialities and limitations of CSF liquid biopsy in achieving molecular characterization of gliomas at first clinical presentation and proposes a protocol to maximize diagnostic information retrievable from CSF DNA.

Keyphrases

cerebrospinal fluid
ultrasound guided
fine needle aspiration
ionic liquid
single molecule
randomized controlled trial
high grade
circulating tumor
inferior vena cava
cell free
healthcare
circulating tumor cells