Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco.
Ping-Chung KuoHsin-Yi HungTsong-Long HwangWen-Ke DuHsiang-Chih KuE-Jian LeeShih-Huang TaiFu-An ChenTian-Shung WuPublished in: Journal of natural products (2017)
Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.
Keyphrases
- anti inflammatory drugs
- anti inflammatory
- signaling pathway
- molecular docking
- high glucose
- high resolution
- diabetic rats
- hydrogen peroxide
- drug induced
- liquid chromatography
- epithelial mesenchymal transition
- pi k akt
- mass spectrometry
- endothelial cells
- high performance liquid chromatography
- nitric oxide
- gas chromatography