Eremophilane Sesquiterpenes and Benzene Derivatives from the Endophyte Microdiplodia sp. WGHS5.
Babar KhanShuangshuang ZhaoZhiyang WangYonghao YeNasir Ahmed RajputWei YanPublished in: Chemistry & biodiversity (2021)
Three new eremophilane sesquiterpenes phomadecalins G-I (1-3) and two new benzene derivatives microdiplzenes A and B (12 and 13), together with nine known eremophilane sesquiterpenes (4-11 and 14) were isolated from an endophytic fungus, Microdiplodia sp. WGHS5. Their structures were elucidated by the interpretation of HR-ESI-MS and NMR data; meanwhile, the absolute configurations of new compounds were determined on the base of ECD calculations. All compounds were evaluated for the antimicrobial activities and antiproliferative effect on human gastric cancer cell lines (BGC-823).
Keyphrases
- ms ms
- high resolution
- endothelial cells
- mass spectrometry
- magnetic resonance
- multiple sclerosis
- structure activity relationship
- density functional theory
- electronic health record
- molecular dynamics
- induced pluripotent stem cells
- molecular dynamics simulations
- big data
- pluripotent stem cells
- solid state
- artificial intelligence